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Xanax is not known to interact with amphetamine/dextroamphetamine (Adderall). However, taking these medications together may not be safe. Adderall is a stimulant medication that’s prescribed for the treatment of attention deficit hyperactive disorder (ADHD). Doctors may sometimes prescribe Xanax with Adderall for people with ADHD who also have anxiety. Taking these medications together for this purpose as prescribed by a doctor is not known to be harmful.

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Yes, it’s typically safe to take a mild pain reliever, such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin), while you’re taking Xanax. However, not all pain relievers are safe to take with Xanax. For example, pain relievers that contain opioids can cause severe side effects and, in rare cases, death if taken with Xanax.* Examples of opioids include codeine, hydrocodone (Hysingla ER), and oxycodone (OxyContin, Xtampza ER, Oxaydo). It’s important to note that some pain-relieving drugs contain acetaminophen in combination with an opioid. Examples include:

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